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Certainty of evidence Paired reviewers with experience in using GRADE assessed the certainty of evidence independently and resolved discrepancies by discussion

20 In adolescents with obesity, semaglutide 2.4 mg once weekly resulted in similar weight loss to that seen in adults (16.1% mean change in body mass index from baseline vs 0.6% with placebo) at 68 weeks with improvement in cardiometabolic risk factors (i.e

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Endoscopic retrograde cholangiopancreatography (ERCP) is another useful diagnostic method

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Williams P, Basu S, Garcia-Manero G, Cortes J, Ravandi F, Al-Hamal Z, Konopleva M, Ning J, Xiao L, Hidalgo-Lopez J, Kornblau S, Andreeff M , Flores W, Bueso-Ramos C, Somani N, Blando J, Al-Atrash G, Allison J, Kantarjian H, Sharma P, Daver N